Lyme Disease

Lyme disease or lyme borreliosis  is an emerging infectious disease caused by at least three species of bacteria belonging to the genus BorreliaBorrelia burgdorferi sensu lato is the main cause of Lyme disease in the United States, whereas Borrelia afzelii and Borrelia garinii cause most European cases.

Lyme disease is the most common tick-borne disease in the Northern Hemisphere. Borrelia is transmitted to humans by the bite of infected ticks .  Early symptoms may include fever, headache, fatigue, depression, and a characteristic circular skin rash called erythema migrans. Left untreated, later symptoms may involve the joints, heart, and central nervous system. In most cases, the infection and its symptoms are eliminated by antibiotics, especially if the illness is treated early. Delayed or inadequate treatment can lead to the more serious symptoms, which can be disabling and difficult to treat. Occasionally, symptoms persist after the infection has been treated with antibiotics, prompting suggestions that Borrelia causes autoimmunity.

Western Blot assay antibody test.

The IgG Western Blot is an immunoassay and qualitative test in which antibodies are visualized.  The IgG antibody is typically present a few months following initial infection.  It is a qualitative test and is generally more sensitive and specific than the ELISA. This test must be used if the Lyme IgG/IgM antibody serology  or  Lyme IgG/IgA/IgM IFA is equivocal or positive.

Highlight: Test to determine if lyme disease is present

Functional Assessment of: IgG Western Blot & IgM Western Blot

Indicated for those with: Undiagnosed symptoms including fever, headache, fatigue, depression, and a characteristic circular skin rash called erythema migrans. Left untreated, later symptoms may involve the joints, heart, and central nervous system.

IgG WESTERN BLOT

A positive IgG result with clinical history may be indicative of Lyme disease. Patients with other spirochetal disease and/or who test positive for rheumatoid factor or Epstein Barr virus may have cross-reacting antibodies. A positive response in this, as in any antibody assay, indicates sensitization, not necessarily active disease

IgM WESTERN BLOT

The IgM Western Blot is a very sensitive indicator of exposure to B. burgdorferi.  It may be positive as early as 1 week after a tick bite.  This test will usually remain positive for six to eight weeks after initial exposure.  Re-exposure will also cause this test to be positive for a brief period of time.  For the testing to be complete, it is preferable that the IgM blot be run along with the IgG blot.

A positive IgM result with clinical history may be indicative of early Lyme disease or persistent infection in otherwise serologically negative individuals.  Recently reported data support our observation that some Lyme patients may have only restricted IgM response to B. burgdorferi.

Information Courtesy of  igenex labs, 2010

Fee Schedule:

295

Consult: 98

The urine test samples are gathered at reviVelife ™ and the results are available 2 weeks after submission.

(It is recommended to have a consult to integrate the results into your optimal health plan )

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